Heartache is an unlockable passive item in Community Remix, a mod for The Binding of Isaac.

Regenerates half soul and half red hearts upon clearing a room.

Complete Boss Rush as Adam.

This item contributes towards the Seraphim transformation. Collecting 3 items from this set will grant Isaac flight and +3 Soul Hearts.

Heartache can be found in the following item pools:

The following tags are applied to this item:

• Check out the item description on the mod's external Wiki.
• Download Community Remix from the Steam Workshop.