Handcuffs is a passive item in David Pack, a mod for The Binding of Isaac.

Enemies have a 50% chance to spawn with the key effect which is indicated by a small key above the enemies head.

If an enemy with the Key effect (or its projectile) collides with Isaac the handcuffs will lock.

While handcuffs are locked:
• Isaac can not use his active item
• Isaac can not pickup items (excluding quest items), trinkets, pills, cards or runes
• Isaac can not collect coins, bombs, or keys
• Isaac can not interact with shops or place bombs
• Enemie's with the key effect have a 10% chance to drop a Handcuffs Key which unlocks the handcuffs when picked up

Handcuffs can be found in the following item pools:

• Download David Pack from the Steam Workshop.