Adrenaline is a passive item in The Binding of Isaac, added in the Afterbirth+ DLC.

Grants damage based on the number of Isaac's fully empty heart containers (half empty containers don't count).

Damage is calculated using the formula: ((2 × MissingHearts) ^ 1.6) × 0.1.

This page shows information as of the latest Repentance release.
To see latest up-to date information about this item for the new Repentance+ (Online Co-op) DLC, check this page instead.

This item contributes towards the Spun transformation. Collecting 3 items from this set will grant Isaac +2 damage, +0.15 speed and spawn a random pill.

Adrenaline can be found in the following item pools:

The following tags are applied to this item:

• Check out the item description on the external Isaac Wiki.