Curse of the Maze! is a curse in The Binding of Isaac.
Entering a new room has a chance to take Isaac to the wrong room, indicated by a subtle screen-shake and sound effect. This can also happen when teleporting between rooms.
Discovered rooms can randomly swap contents with another room of the same size.
This page shows information as of the latest Repentance release.
To see latest up-to date information about this curse for the new Repentance+ (Online Co-op) DLC, check this page instead.