Essence of Cain is an unlockable consumable in Epiphany, a mod for The Binding of Isaac.

Reseals every open chest and every broken Slot Machine in the room, allowing for new rewards to be obtained from them.

Defeat Hush and Boss Rush as Tarnished Cain.

The following special synergies and interactions for Essence of Cain have been documented.

* Note that not all possible synergies and interactions are listed here.

The following sounds are related to this consumable.

• Check out the consumable description on the mod's external Wiki.
• Download Epiphany from the Steam Workshop.