Isaac's Heart is an unlockable familiar in The Binding of Isaac.

Spawns a heart familiar that follows Isaac and tries to position itself in the opposite direction of Isaac's shooting.

Isaac takes damage if the heart is hurt, but Isaac's body becomes immune to damage, excluding interactable objects such as Blood Donation Machines and Devil Beggars.

The heart charges up as Isaac fires. At full charge, upon releasing the fire button, it will knock back nearby enemies and tears, create a small puddle of red creep, and release blood shots in 8 directions that deal 8 damage.

Makes Isaac's body deal contact damage equal to 2x Isaac's damage stat per tick (4x per second).

This page shows information as of the latest Repentance release.
To see latest up-to date information about this item for the new Repentance+ (Online Co-op) DLC, check this page instead.

Defeat Isaac as The Lost

Isaac's Heart can be found in the following item pools:

The following tags are applied to this item:

The following special synergies and interactions for Isaac's Heart have been documented.

* Note that not all possible synergies and interactions are listed here.

• Check out the item description on the external Isaac Wiki.