Exploding Head Syndrome! is a challenge in Alphabirth+, a mod for The Binding of Isaac.

Pseudobulbar Affect
Ipecac
Continuum
Spoon Bender

Note: this list does not include characters' default starting items.

Isaac is blindfolded and only shoots transcendent ipecac tears in the direction he moves.

The following is unlocked for completing the Exploding Head Syndrome! challenge: Glitched Pickups

• Download Alphabirth+ from the Steam Workshop.