Challenges
| Name | Character | Starting items | Disabled rooms | Curse filters | Additional notes | End goal | Unlock condition | Reward |
|---|---|---|---|---|---|---|---|---|
| 1. [ddad]Don't Hurt Your Leg | Cain | Joint Effusion (x4)
Wooden Spoon | - | Items will disappear after 10s. Items in the boss room cycles between the original item and Blood Bag. Items outside of boss room cycles between the original item and Joint Effusion | Mom | - | - | |
| 2. [ddad]Curse of the Skull | The Forgotten | Brother Bobby
Sister Maggy Mongo Baby Compound Fracture Pointy Rib Brittle Bones Bone Spurs | - | Familiar's tears can deal damage to The Forgotten. When a familiar deals damage to The Forgotten, he will be transform into Dry Baby for one room. | Mom | - | - | |
| 3. [ddad]Out of Control | Lazarus | Non-responsible Aggregates
Chaos | - | Isaac can no longer vote for any proposal, and vote beggars will not appear. Item has a chance to become blind items. Spawns Forget Me Now every floor. Upon leaving the starting room, remove Forget Me Now. | Satan | - | - | |
| 4. [ddad]Money!!! | Judas | Money = Power
Restock Pay To Play Deep Pockets Money Worship Fanclub Lights Work for Nothing Key Piece 1 Key Piece 2 | - | - | All hearts, bombs, keys, consumables, batteries and trinkets turn into coins. Upon entering next floor, remove half of Judas' coins, and spawns Work for Nothing if Judas do not have one. | The Lamb | - | - |
| 5. [ddad]Alcoholic fiend | Judas | Cocktail Shaker
Deep Pockets NO! (smelted) | - | Permanent Tipsy effect.
If there's no drink effect available, Judas is forced to triggers a random drink and consumes his coins. If he didn't have enough coins, triggers IV Bag. | The Lamb | Unlock Cocktail Shaker. | - | |
| 6. [ddad]Basement #8 | ??? | - | - | You are trapped in an endless basement. Observe your surroundings carefully to reach The End Goal. Don't overlook any anomalies. If you find anomalies, turn back immediately. If you don't find anomalies, do not turn back. You have at most 6 chances for mistakes. To go out from Basement 8. | Successfully pass 8 rooms | - | - | |
| 7. [ddad]Vocabulary Test | Isaac | Isaac's Alphabet
Analog Stick | - | Isaac needs to move with direction keys. Upon pressing any Letter key, Isaac automatically shoots at the nearest enemy with corresponding letter. If there's no enemy nearby, Isaac can use WASD to shoot in the corresponding direction. Enemies' HP will increases by 100% every floor. | Isaac | - | - | |
| 8. [ddad]Sniper Duel | Isaac | Marked
Anima Sola | - | - | Increases enemies' shot speed. When the crossair gets close to an enemy, Isaac begins to charge, then he'll shoot at the crossair, dealing 10x Isaac's damage. The charge speed can be affected by Isaac's tears stat. | Mom | - | Water Drop |
| 9. [ddad]Soul Painter | The Lost No HP. | Transcendental Stroke
| - | - | Upon entering a room for the first time, all item pedestrals turns into Mysterious Paper. More inks. | ??? | - | - |