Challenges
| Name | Character | Starting items | Disabled rooms | Curse filters | Additional notes | End goal | Unlock condition | Reward |
|---|---|---|---|---|---|---|---|---|
| 1. Ultimate cards | Isaac | Starter Deck
Card Reading Schoolbag Deck of Cards  c789
Blank Card | - | Every stage have Curse of Cards. It's forced, and cannot be removed. | Satan | Unlock  Bethany and  Gabriel | Stefan | |
| 2. I killed myself? | Isaac | Holy Outburst
| - | Other Active items cannot appear | Isaac | Defeat Mega Satan | Gabriel | |
| 3. i knueorclCc | Crice | Missing No.
Telepills | - | - | - | Mom's Heart | Complete Challenge 45 | Crice |
| 4. PSYCHO | Isaac | Isaac's Heart
Psychopathic Mom's Knife | - | - | ±2.5 damage. | Mom's Heart | Defeat Satan as Gabriel |  Enty |
| 5. Alternative Greed? | Isaac | - | - | - | - | Ultra Greed | Complete Greedier as Keeper | Alt Path in Greed Mode |