Challenges
| Name | Character | Starting items | Disabled rooms | Curse filters | Additional notes | End goal | Unlock condition | Reward |
|---|---|---|---|---|---|---|---|---|
| 1. [DAMN] Sacrificial Ceremony | Judas | Birthright
God's Indiscriminate Wrath (consumable slot) | - | God's Indiscriminate Wrath can be used for infinite times. | The Lamb | Unlock Stary's Head. | Murder Diary | |
| 2. [DAMN] Cry Your Own Epitaph |  Rainy DollNo HP. | - | - | - | - | ??? | Unlock The Polaroid. | The Rainy Doll |
| 3. [DAMN] The Watcher | Judas | Schoolbag
How to Jump Blasphemy (passive) | - | - | Mom's Heart | Unlock Judas. | Blasphemy | |
| 4. [DAMN] American PokeGo | Isaac | Dr. Fetus
Poke Go | - | Enemies die from explosion will revive and becomes friendly enemy. When Isaac has more than 6 friendly enemies, immediately kills them and spawns a random trinket. | Mom | Unlock Dr. Fetus | Slaver's Whip | |
| 5. [DAMN] Exam Oriented Education | Isaac | The D6
| - | - | If Isaac did not take penalty damage for the entire floor, spawns a golden Perfection upon clearing the boss room. If Isaac tries to collide Trophy with less than 90 luck, remove all items Isaac has, and teleport Isaac to the boss rush (to get rid of Internet Addiction). Under this circumstance, every wave clear without taking damage offers 2 Perfection, clearing all waves spawns a Trophy. | The Lamb | Unlock The Negative. |  Juzzle (WIP) |