Challenges
| Name | Character | Starting items | Disabled rooms | Curse filters | Additional notes | End goal | Unlock condition | Reward |
|---|---|---|---|---|---|---|---|---|
| 1. [GOD] Secrets | Isaac | - | - | - | Not an actual challenge.
It's just here to list all the Achievements, their unlocks and let Isaac try the unlocked items. | Other | - | - |
| 2. [GOD] Sugar Rush! | Isaac | Sugar! x4 | - | All items have the inherent 50% chance to convert into Sugar!, regardless of if there is rolls left from the item itself. | Mom | - | Sugar! | |
| 3. [GOD] The Galactic Approach | Isaac | Celestial Collar Celestial Paw Celestial Tail | - | +10 damage. | Mom's Heart | - | Celestial Collar Celestial Paw Celestial Tail | |
| 4. [GOD] Out Of Time | Isaac | Death's Touch
Lord of the Pit Ceremonial Robes | Call of the Void's Faithless charges are immediately activated on entering a new floor. | Mom | - | A Second Thought | ||
| 5. [GOD] Tainted Sign Preview! | The Sign | - | - | - | Allow to playtest a beta version of Tainted Sign. | Mom | - | - |