Pica Run is an unlockable challenge in The Binding of Isaac, added in the Repentance DLC.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this challenge for the previous Repentance version, check this page instead.

Mom's Purse
Marbles
Mom's Box

Note: this list does not include characters' default starting items.

All items are replaced with trinkets.
Marbles activates on every hit.

The following is unlocked for completing the Pica Run challenge: Ice Cube

Defeat Mom's Heart 11 times and unlock Marbles.

• Check out the challenge description on the external Isaac Wiki.